Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 47 0.0 0.465 0.031 0.086
biological_process el 47 0.06 0.966 0.623 0.25
biological_process ka 47 0.0 0.451 0.029 0.082
biological_process rf 47 0.0 0.465 0.031 0.086
cellular_component ct 47 0.0 0.583 0.056 0.11
cellular_component el 47 0.0 1.0 0.534 0.299
cellular_component ka 47 0.0 0.579 0.059 0.113
cellular_component rf 47 0.0 0.583 0.056 0.11
disease ct 12 0.001 0.839 0.188 0.256
disease el 12 0.005 0.791 0.348 0.253
disease ka 12 0.0 0.756 0.182 0.246
disease rf 12 0.001 0.838 0.188 0.256
genetic_interaction ct 43 0.0 1.0 0.402 0.341
genetic_interaction el 43 0.0 1.0 0.397 0.335
genetic_interaction ka 43 0.0 0.302 0.13 0.086
genetic_interaction rf 43 0.0 1.0 0.402 0.341
molecular_function ct 47 0.0 0.797 0.026 0.117
molecular_function el 47 0.02 0.942 0.4 0.289
molecular_function ka 47 0.0 0.773 0.027 0.116
molecular_function rf 47 0.0 0.797 0.027 0.117
pathway ct 25 0.0 0.996 0.061 0.194
pathway el 25 0.0 0.185 0.018 0.038
pathway ka 25 0.0 0.045 0.01 0.016
pathway rf 25 0.0 0.15 0.02 0.035
phenotype ct 13 0.0 0.881 0.319 0.32
phenotype el 13 0.176 0.837 0.489 0.189
phenotype ka 13 0.0 0.938 0.356 0.347
phenotype rf 13 0.0 0.879 0.318 0.319
protein_interaction ct 49 0.0 0.235 0.009 0.033
protein_interaction el 49 0.0 0.178 0.008 0.025
protein_interaction ka 49 0.0 0.012 0.001 0.003
protein_interaction rf 49 0.0 0.227 0.009 0.032

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 49 0.0 0.728 0.03 0.112
integration_mean_by_presence el 49 0.0 0.703 0.11 0.152
integration_mean_by_presence ka 49 0.0 0.811 0.023 0.115
integration_mean_by_presence rf 49 0.0 0.229 0.012 0.034
mean ct 49 0.0 0.681 0.023 0.103
mean el 49 0.0 0.53 0.049 0.101
mean ka 49 0.0 0.587 0.018 0.085
mean rf 49 0.0 0.245 0.019 0.056

CDF plots of non integrated kernels

CDF plots of integrated kernels